Published Research on Appendix Cancer

Surgical Oncology Research at Mercy Medical Center Information

Appendix Cancer Research

The 7th Edition of the AJCC Staging Classification Correlates with Biologic Behavior of Mucinous Appendiceal Tumor with Peritoneal Metastases Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC).

Milovanov V, Sardi A, Studeman K, Nieroda C, Sittig M, Gushchin V.

Ann Surg Oncol. 2016 Jun;23(6):1928-33. doi: 10.1245/s10434-015-5047-5. Epub 2015 Dec 29.

PMID: 26714951

Approach to the Porta Hepatis During Cytoreductive Surgery: Technical Considerations.

Aydin N, Sardi A, Milovanov V.

Ann Surg Oncol. 2016 Feb;23(2):552-5. doi: 10.1245/s10434-015-4872-x.

PMID: 26577121

Extensive surgical history prior to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is associated with poor survival outcomes in patients with peritoneal mucinous carcinomatosis of appendiceal origin.

Milovanov V, Sardi A, Aydin N, Nieroda C, Sittig M, Nunez M, Gushchin V.

Eur J Surg Oncol. 2015 Jul;41(7):881-5. doi: 10.1016/j.ejso.2015.02.016. Epub 2015 Apr 13.

PMID: 25899982

Systemic chemotherapy (SC) before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) in patients with peritoneal mucinous carcinomatosis of appendiceal origin (PMCA).

Milovanov V, Sardi A, Ledakis P, Aydin N, Nieroda C, Sittig M, Nunez M, Gushchin V.

Eur J Surg Oncol. 2015 May;41(5):707-12. doi: 10.1016/j.ejso.2015.01.005. Epub 2015 Jan 17.

PMID: 25633641

Multicentre study of the learning curve and surgical performance of cytoreductive surgery with intraperitoneal chemotherapy for pseudomyxoma peritonei.

Kusamura S, Moran BJ, Sugarbaker PH, Levine EA, Elias D, Baratti D, Morris DL, Sardi A, Glehen O, Deraco M; Peritoneal Surface Oncology Group International (PSOGI).

Br J Surg. 2014 Dec;101(13):1758-65. doi: 10.1002/bjs.9674. Epub 2014 Oct 20.

PMID: 25329419

Port-site metastases is an independent prognostic factor in patients with peritoneal carcinomatosis.

Nunez MF, Sardi A, Jimenez W, Nieroda C, Sittig M, MacDonald R, Aydin N, Milovanov V, Gushchin V.

Ann Surg Oncol. 2015 Apr;22(4):1267-73. doi: 10.1245/s10434-014-4136-1. Epub 2014 Oct 16.

PMID: 25319578

Morbidity of the abdominal wall resection and reconstruction after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).

Nunez MF, Sardi A, Nieroda C, Jimenez W, Sittig M, MacDonald R, Aydin N, Milovanov V, Gushchin V.

Ann Surg Oncol. 2015 May;22(5):1658-63. doi: 10.1245/s10434-014-4075-x. Epub 2014 Sep 23.

PMID: 25245127

Progression of peritoneal adenomucinosis to the scrotum: a rare occurrence treated with cytoreductive surgery and hyperthermic chemoperfusion of the scrotum in two patients.

Sardi A, Jiménez WA, Wosu C.

Colomb Med (Cali). 2014 Jun 30;45(2):77-80. eCollection 2014 Apr-Jun.

PMID: 25100893
Free PMC Article

The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with Mitomycin C versus Oxaliplatin in 539 patients with colon cancer undergoing a complete cytoreductive surgery.

Prada-Villaverde A, Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, González-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Salti G, Sardi A, Senthil M, Spiliotis J, Torres-Melero J, Turaga K, Trout R.

J Surg Oncol. 2014 Dec;110(7):779-85. doi: 10.1002/jso.23728. Epub 2014 Aug 2.

PMID: 25088304

Predictive and prognostic survival factors in peritoneal carcinomatosis from appendiceal cancer after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.

Jimenez W, Sardi A, Nieroda C, Sittig M, Milovanov V, Nunez M, Aydin N, Gushchin V.

Ann Surg Oncol. 2014 Dec;21(13):4218-25. doi: 10.1245/s10434-014-3869-1. Epub 2014 Jul 2.

PMID: 24986239

The American Society of Peritoneal Surface Malignancies (ASPSM) Multiinstitution Evaluation of the Peritoneal Surface Disease Severity Score (PSDSS) in 1,013 Patients with Colorectal Cancer with Peritoneal Carcinomatosis.

Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, González-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Salti G, Sardi A, Senthil M, Spilioitis J, Torres-Melero J, Turaga K, Trout R.

Ann Surg Oncol. 2014 Dec;21(13):4195-201. doi: 10.1245/s10434-014-3798-z. Epub 2014 May 23.

PMID: 24854493

Melphalan: a promising agent in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

Sardi A, Jimenez W, Nieroda C, Sittig M, Shankar S, Gushchin V.

Ann Surg Oncol. 2014 Mar;21(3):908-14. doi: 10.1245/s10434-013-3407-6. Epub 2013 Nov 26.

PMID: 24276642

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of recurrent high-grade uterine sarcoma with peritoneal dissemination.

Jimenez WA, Sardi A, Nieroda C, Gushchin V.

Am J Obstet Gynecol. 2014 Mar;210(3):259.e1-8. doi: 10.1016/j.ajog.2013.11.002. Epub 2013 Nov 7.

PMID: 24211479

The role of VEGFR-2 expression in outcomes and survival of patients with peritoneal carcinomatosis from appendiceal cancer.

Jimenez WA, Sardi A, Ledakis P, Nieroda C, Sittig M, Gushchin V.

Eur J Surg Oncol. 2013 Dec;39(12):1415-22. doi: 10.1016/j.ejso.2013.08.032. Epub 2013 Sep 12.

PMID: 24075030

Repeated cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from appendiceal cancer: analysis of survival outcomes.

Sardi A, Jimenez WA, Nieroda C, Sittig M, Macdonald R, Gushchin V.

Eur J Surg Oncol. 2013 Nov;39(11):1207-13. doi: 10.1016/j.ejso.2013.08.017. Epub 2013 Sep 2.

PMID: 24007834

A core microbiome associated with the peritoneal tumors of pseudomyxoma peritonei.

Gilbreath JJ, Semino-Mora C, Friedline CJ, Liu H, Bodi KL, McAvoy TJ, Francis J, Nieroda C, Sardi A, Dubois A, Lazinski DW, Camilli A, Testerman TL, Merrell DS.

Orphanet J Rare Dis. 2013 Jul 12;8:105. doi: 10.1186/1750-1172-8-105.

PMID: 23844722
Free PMC Article

Consensus guidelines from The American Society of Peritoneal Surface Malignancies on standardizing the delivery of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients in the United States.

Turaga K, Levine E, Barone R, Sticca R, Petrelli N, Lambert L, Nash G, Morse M, Adbel-Misih R, Alexander HR, Attiyeh F, Bartlett D, Bastidas A, Blazer T, Chu Q, Chung K, Dominguez-Parra L, Espat NJ, Foster J, Fournier K, Garcia R, Goodman M, Hanna N, Harrison L, Hoefer R, Holtzman M, Kane J, Labow D, Li B, Lowy A, Mansfield P, Ong E, Pameijer C, Pingpank J, Quinones M, Royal R, Salti G, Sardi A, Shen P, Skitzki J, Spellman J, Stewart J, Esquivel J.

Ann Surg Oncol. 2014 May;21(5):1501-5. doi: 10.1245/s10434-013-3061-z. Epub 2013 Jun 21. Review.

PMID: 23793364

Antibiotic treatment decreases microbial burden associated with pseudomyxoma peritonei and affects β-catenin distribution.

Semino-Mora C, Testerman TL, Liu H, Whitmire JM, Studeman K, Jia Y, McAvoy TJ, Francis J, Nieroda C, Sardi A, Merrell DS, Dubois A.

Clin Cancer Res. 2013 Jul 15;19(14):3966-76. doi: 10.1158/1078-0432.CCR-13-0616. Epub 2013 Jun 6.

PMID: 23743566
Free Article

Neoplasms of the appendix: current treatment guidelines.

Shankar S, Ledakis P, El Halabi H, Gushchin V, Sardi A.

Hematol Oncol Clin North Am. 2012 Dec;26(6):1261-90. doi: 10.1016/j.hoc.2012.08.010. Epub 2012 Oct 9. Review.

PMID: 23116580

Delay of cytoreductive surgery and heated intraperitoneal chemotherapy in patients with appendiceal neoplasm.

El Halabi H, MacDonald R, Studeman K, Francis J, Nieroda C, Gushchin V, Sardi A.

Am Surg. 2012 Jul;78(7):745-8.

PMID: 22748531

Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

Chua TC, Moran BJ, Sugarbaker PH, Levine EA, Glehen O, Gilly FN, Baratti D, Deraco M, Elias D, Sardi A, Liauw W, Yan TD, Barrios P, Gómez Portilla A, de Hingh IH, Ceelen WP, Pelz JO, Piso P, González-Moreno S, Van Der Speeten K, Morris DL.

J Clin Oncol. 2012 Jul 10;30(20):2449-56. doi: 10.1200/JCO.2011.39.7166. Epub 2012 May 21.

PMID: 22614976

Prognostic significance of lymph node metastases in patients with high-grade appendiceal cancer.

Halabi HE, Gushchin V, Francis J, Athas N, Macdonald R, Nieroda C, Studeman K, Sardi A.

Ann Surg Oncol. 2012 Jan;19(1):122-5. doi: 10.1245/s10434-011-1903-0. Epub 2011 Jul 12.

PMID: 21748246

The role of cytoreductive surgery and heated intraperitoneal chemotherapy (CRS/HIPEC) in patients with high-grade appendiceal carcinoma and extensive peritoneal carcinomatosis.

El Halabi H, Gushchin V, Francis J, Athas N, Macdonald R, Nieroda C, Studeman K, Sardi A.

Ann Surg Oncol. 2012 Jan;19(1):110-4. doi: 10.1245/s10434-011-1840-y. Epub 2011 Jun 24.

PMID: 21701929

Accuracy and clinical relevance of computed tomography scan interpretation of peritoneal cancer index in colorectal cancer peritoneal carcinomatosis: a multi-institutional study.

Esquivel J, Chua TC, Stojadinovic A, Melero JT, Levine EA, Gutman M, Howard R, Piso P, Nissan A, Gomez-Portilla A, Gonzalez-Bayon L, Gonzalez-Moreno S, Shen P, Stewart JH, Sugarbaker PH, Barone RM, Hoefer R, Morris DL, Sardi A, Sticca RP.

J Surg Oncol. 2010 Nov 1;102(6):565-70. doi: 10.1002/jso.21601.

PMID: 20976729

Clinical utility of elevated tumor markers in patients with disseminated appendiceal malignancies treated by cytoreductive surgery and HIPEC.

Ross A, Sardi A, Nieroda C, Merriman B, Gushchin V.

Eur J Surg Oncol. 2010 Aug;36(8):772-6. doi: 10.1016/j.ejso.2010.05.024. Epub 2010 Jun 18.

PMID: 20561764

Complete cytoreduction offers longterm survival in patients with peritoneal carcinomatosis from appendiceal tumors of unfavorable histology.

Omohwo C, Nieroda CA, Studeman KD, Thieme H, Kostuik P, Ross AS, Holter DR, Gushchin V, Merriman B, Sardi A.

J Am Coll Surg. 2009 Sep;209(3):308-12. doi: 10.1016/j.jamcollsurg.2009.04.019. Epub 2009 Jul 9.

PMID: 19717034

Pseudomyxoma peritonei: is disease progression related to microbial agents? A study of bacteria, MUC2 AND MUC5AC expression in disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis.

Semino-Mora C, Liu H, McAvoy T, Nieroda C, Studeman K, Sardi A, Dubois A.

Ann Surg Oncol. 2008 May;15(5):1414-23. doi: 10.1245/s10434-007-9778-9. Epub 2008 Feb 26.

PMID: 18299935
Free PMC Article

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology.

Esquivel J, Sticca R, Sugarbaker P, Levine E, Yan TD, Alexander R, Baratti D, Bartlett D, Barone R, Barrios P, Bieligk S, Bretcha-Boix P, Chang CK, Chu F, Chu Q, Daniel S, de Bree E, Deraco M, Dominguez-Parra L, Elias D, Flynn R, Foster J, Garofalo A, Gilly FN, Glehen O, Gomez-Portilla A, Gonzalez-Bayon L, Gonzalez-Moreno S, Goodman M, Gushchin V, Hanna N, Hartmann J, Harrison L, Hoefer R, Kane J, Kecmanovic D, Kelley S, Kuhn J, Lamont J, Lange J, Li B, Loggie B, Mahteme H, Mann G, Martin R, Misih RA, Moran B, Morris D, Onate-Ocana L, Petrelli N, Philippe G, Pingpank J, Pitroff A, Piso P, Quinones M, Riley L, Rutstein L, Saha S, Alrawi S, Sardi A, Schneebaum S, Shen P, Shibata D, Spellman J, Stojadinovic A, Stewart J, Torres-Melero J, Tuttle T, Verwaal V, Villar J, Wilkinson N, Younan R, Zeh H, Zoetmulder F, Sebbag G; Society of Surgical Oncology Annual Meeting.

Ann Surg Oncol. 2007 Jan;14(1):128-33. Epub 2006 Oct 28. No abstract available. Erratum in: Ann Surg Oncol. 2011 Dec;18 Suppl 3:S334-5.

PMID: 17072675